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Hell o! I)Serologic markers of hepatic fibrosis can broadly be categorized as indirect or direct: ●Indirect markers reflect alterations in hepatic function, but do not directly reflect extracellular matrix metabolism. Examples include the platelet count, coagulation studies, and liver aminotransferases. ●Direct markers of fibrosis reflect extracellular matrix turnover. Examples include procollagen types I and III, hylauronic acid , and tissue inhibitor of metalloproteinase . II)Permissive role of hormone- It means that the hormone enhances the action of another hormone. LEPTIN- It has an important permissive role in the progression into puberty and the maintenance of normal hypothalamic-pituitary-gonadal function. KISSPEPTIN- It is a principle activator of GnRH neurons and is a pre-requisite for the onset of puberty and maintenance of normal reproductive function. It is a neuropeptide. Loss of function mumtation of kisspeptin receptor gene (KISS1R) ...