Random must-to-know

Hello!

I)Serologic markers of hepatic fibrosis can broadly be categorized as indirect or direct: 
●Indirect markers reflect alterations in hepatic function, but do not directly reflect extracellular matrix metabolism. Examples include the platelet count, coagulation studies, and liver aminotransferases.

●Direct markers of fibrosis reflect extracellular matrix turnover. Examples include procollagen types I and III,hylauronic acid, and tissue inhibitor of metalloproteinase.

II)Permissive role of hormone-
It means that the hormone enhances the action of another hormone.

LEPTIN- It has an important permissive role in the progression into puberty and the maintenance of normal hypothalamic-pituitary-gonadal function.

KISSPEPTIN- It is a principle activator of GnRH neurons and is a pre-requisite for the onset of puberty and maintenance of normal reproductive function.
It is a neuropeptide. Loss of function mumtation of kisspeptin receptor gene (KISS1R) are associated with pubertal failure.

III) Pleural fluid in pulmonary embolism is Exuadate-
The release of inflammatory mediators from platelet-rich thrombi can increase the permeability of the capillaries in either the visceral pleura or the lung resulting in exudation of proteins in pleural space. Ischemia of the pulmonary capillaries distal to the embolus also contributes to the increased permeability.

IV) Calcium itself is a clotting factor. It is required for many steps in coagulation pathway.
Factor 2,3,7,8,9,10. 

V) Thromboelastogram



VI) Insulin:-
Insulin Analogue




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 Hope this will help.
-Upasana Y.

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