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Hello ! Q. On peripheral blood smears there is presence of  spherocytes . What are the differentials and the test to identify the same? Most of you have prompted it as hereditary spherocytosis.  Let see. Ans.  DIFFERENTIALS :-  HEREDITARY SPHEROCYTOSIS AUTO-IMMUNE HEMOLYTIC ANEMIA  Best next step is to do  DIRECT COOMBS TEST  to rule out autoimmune hemolytic anemia. For hereditary spherocytosis go for osmotic fragility test.     So spherocytosis doesn't means Hereditary, it could be acquired, usually preceded by an infection. HAPPY STUDYING :)  - Upasana Y.