Drug interactions-1 (Notes from KDT)
Definition:-
Modification of response to one drug by another drug or non drug (like food ,beverageslike alcohol,smoking) when they are administered simultaneously or in quick succession .
Factors for drug interactions:-
1.Multiple drugs for same disease.
2.Multiple prescribers.
3.Multiple diseases.
4.Poor patient compliance .
5. Drug factors like it is not palatable or too many in frequency .
6.Multiple unknown action of drugs.
7. Most imp is patients age .
Effects of drug interaction:-
1.Quantitative i.e Increase or decrease the response intensity.
2. Qualitative:- abnormal /different type of response.
Mechanism of drug interaction :-
A.Pharmacokinetic interactions include,
1.Absorption (either complex formation ,pH change ,or alteration in motility of GIT.)
2. Distribution:- (displacement from plasma protein binding site + inhibition of metabolism /or excretion)
3. Metabolism:- ( induction of enzymes or inhibition of enzymes or hepatic blood flow)
4.Excretion:- ( alteration in urine pH, Competition for active secretion ,renal blood flow)
B. Pharmacodynamic drug interactions include,
1.Antagonism
2. Summation
3.synergism
C.Drug interaction before administration:-
Either mixing before administration.
Or, exposure to light in some cases. (Like sodium nitroprusside).
-Upasana Y.
Modification of response to one drug by another drug or non drug (like food ,beverageslike alcohol,smoking) when they are administered simultaneously or in quick succession .
Factors for drug interactions:-
1.Multiple drugs for same disease.
2.Multiple prescribers.
3.Multiple diseases.
4.Poor patient compliance .
5. Drug factors like it is not palatable or too many in frequency .
6.Multiple unknown action of drugs.
7. Most imp is patients age .
Effects of drug interaction:-
1.Quantitative i.e Increase or decrease the response intensity.
2. Qualitative:- abnormal /different type of response.
Mechanism of drug interaction :-
A.Pharmacokinetic interactions include,
1.Absorption (either complex formation ,pH change ,or alteration in motility of GIT.)
2. Distribution:- (displacement from plasma protein binding site + inhibition of metabolism /or excretion)
3. Metabolism:- ( induction of enzymes or inhibition of enzymes or hepatic blood flow)
4.Excretion:- ( alteration in urine pH, Competition for active secretion ,renal blood flow)
B. Pharmacodynamic drug interactions include,
1.Antagonism
2. Summation
3.synergism
C.Drug interaction before administration:-
Either mixing before administration.
Or, exposure to light in some cases. (Like sodium nitroprusside).
-Upasana Y.
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