When the Thymus Tells a Story: Evaluating Thymic Abnormalities in a Child With Suspected Myasthenia
Hello Glias ! Today’s pediatric case was a 7-year-old with signs suggestive of myasthenia gravis — fatigability and ptosis — but negative for anti–acetylcholine receptor antibodies . Given the presentation, our task was to rule out thymic pathology , particularly thymoma or thymic hyperplasia , on imaging. Why the Thymus Matters in Pediatrics The thymus, though often forgotten after infancy, plays a central role in T-cell maturation and immune regulation. It enlarges rapidly in infancy , peaks at puberty , and then involutes gradually , replaced by fat with age. However, in children, normal thymus can appear large — and this can easily raise unnecessary alarms unless interpreted in the right context. 📚 According to Manchanda et al. (WJCP, 2017) : “The thymus attains maximum weight at puberty and gradually becomes replaced by fat and involutes with age. However, it can grow back (rebound) after stress or...